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Researchers have discoveredcoronaviruseslurking in Laotian bat that appear to be the closest known relatives to SARS - CoV-2 , the virus that causes COVID-19 , found to date , according to news reports .
In a young subject field , researcher from the Pasteur Institute in France and the University of Laos captured 645 bats from limestone caves in northern Laos and sort them for virus related to SARS - CoV-2 . They found three virus — which they dub BANAL-52 , BANAL-103 and BANAL-236 — that infected shoe chiropteran and shared more than 95 % of their overall genome with SARS - CoV-2 .
One of the viruses , BANAL-52 , was 96.8 % superposable to SARS - CoV-2 , consort toNature News . That makes BANAL-52 more genetically like to SARS - CoV-2 than any other known virus . Previously , the nighest know relative to SARS - CoV-2 was RaTG13 , which was regain in horseshoe bat in 2013 and share 96.1 % of its genome with SARS - CoV-2 , Nature News reported .
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What ’s more , all three of the newly discovered viruses are more standardised to SARS - CoV-2 in a key part of their genome — called the receptor binding domain of a function ( RBD ) — than other knownviruses . The RBD is the part of the virus that allows it to tie to master of ceremonies cells . With SARS - CoV-2 , the RBD binds to a receptor known as ACE2 on human cells , and the computer virus uses this sensory receptor as a gateway into cells .
Critically , the new study found that BANAL-52 , BANAL-103 and BANAL-236 can adhere to ACE2 and apply it to record human cells . So far , other candidates advise as antecedent of SARS - CoV-2 found in bat , including RaTG13 , have n’t been capable to do this , the researchers enounce . The three viruses could bind to ACE2 about as well as early strains of SARS - CoV-2 found in Wuhan , they say .
The findings , which were posted to the preprint serverResearch Squareon Sept. 17 , add to the grounds thatSARS - CoV-2 had a natural origin , rather than turn tail from a lab .
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The results show " that sequences very close to those of the early var. of SARS - CoV-2 … be in nature , " the researchers wrote in their paper , which has yet to be peer - review .
" The receptor binding domain of SARS - CoV-2 looked unusual when it was first discovered because there were so few virus to compare it to , " Edward Holmes , an evolutionary life scientist at the University of Sydney , who was n’t involved in the research , toldBloomberg . " Now that we are sampling more from nature , we are starting to regain these closely relate bits of gene sequence , " Holmes tell .
The authors say their findings support the supposition that SARS - CoV-2 resulted from a recombination of viral episode existing in horseshoe bats .
Still , even though the newly discovered viruses are closely link to SARS - CoV-2 , all three virus lack a sequence for what is hump as the " furin cleavage site , " which is seen in SARS - CoV-2 and aids the computer virus ’s entree into cadre , according to Nature News . This means that in decree to well understand the origins of SARS - CoV-2 further research is require to show how and when the furin land site was enclose .
The findings are currently being regard for publishing in a Nature journal , Bloomberg reported .
primitively published on Live Science .
